AurimMed Pharma is supported by a number of highly recognized Scientific and Medical Advisors who generously volunteer their time & expertise in order to advance the Company's scientific and preclinical programs.
AurimMed Pharma, Inc. has established long-term, professional collaborations with scientific and medical experts who serve on the Company’s Scientific and Medical Advisory Panel (SMAP). This Advisory Panel consists of a world-class group of scientists, medical doctors, and researchers with expertise relevant to the Company’s areas of product development. Collaborations between AurimMed and the individual advisors are based on mutual scientific, medical, and business interests.
Several of AurimMed's lead candidate compounds have been deemed worthy of undergoing advanced preclinical testing and development through the NIH's Anticonvulsant Screening Program. The promising results that have been obtained so far with the Company's top three preclinical candidates strongly suggest that the selection of a clinical candidate to enter Phase I human clinical trials could occur within as little as 12 months. Therefore, highly regarded scientific and medical experts are needed to help provide professional guidance and advice for the advancement of AurimMed’s scientific programs, as well as for the design and implementation of the Company’s future clinical trials. The professional qualifications of the Members of AurimMed Pharma’s SMAP represent this high level of expertise, and SMAP Members regularly contribute their professional input at a high level to the Company's future evolution and development.
Matthew E. R. Butchbach, Ph.D., is a Research Scientist and Head of the Motor Neuron Diseases Research Laboratory at Nemours/Alfred I. duPont Hospital for Children. He is also a Research Assistant Professor in the Department of Pediatrics at the Sidney Kimmel Medical College of Thomas Jefferson University and an Adjunct Assistant Professor in the Department of Biological Sciences at the University of Delaware. Dr. Butchbach attended the Ohio University (B.S., 1995; B.A., 1995) and the Ohio State University (M.S., 2000) and earned his doctorate in biochemistry from the Ohio State University (Ph.D., 2003). He completed his postdoctoral training with Dr. Arthur Burghes at the Ohio State University (2003-2008) and was also a Research Scientist in the Department of Molecular and Cellular Biochemistry (2008-2011).
For the past 13 years, Dr. Butchbach’s research has focused on preclinical drug discovery for the pediatric-onset motor neuron disease, spinal muscular atrophy (SMA). His research focuses on the identification and development of small-molecule activators of SMN2 expression, an important endogenous modifier of SMA severity. He is also interesting in developing new neuroprotective agents for SMA—as well as for other motor neuron diseases like amyotrophic lateral sclerosis. He has served on numerous committees related to preclinical drug testing in mouse models for SMA. Dr. Butchbach has authored or co-authored 29 peer-reviewed publications to date.
Chris M. Ireland, Ph.D., is the Chief Administrative Officer and Associate Vice President for Research for The University of Utah Asia Campus. He joined the faculty of the University of Utah as an Assistant Professor of Medicinal Chemistry in 1983 and most recently was the L. S. Skaggs Presidential Endowed Chair for Pharmacy and Dean.
During his 26 years on the faculty he has established himself as a world leader in the field of natural product drug discovery. Dr. Ireland’s research program has focused on the discovery of antitumor agents from natural product sources including marine invertebrate animals, tropical plants and fungi. He and his co-workers have published more than 170 peer reviewed research articles, eight book chapters and five patents. His research accomplishments and international reputation have been acknowledged in the form of numerous invitations to speak at national and international symposia on natural products research and cancer chemotherapeutics. Dr. Ireland has received additional recognition by serving on a number of review panels at NIH including the Bioorganic and Natural Products NIH study section and most recently as a member of the National Cancer Institute’s Board of Scientific Counselors. Dr. Ireland has served as the Principal Investigator of a National Cooperative Drug Discovery Group consortium funded by the NCI to discover new cancer drugs from unique natural products sources, and is currently serving as the Co-PI of an International Cooperative Biodiversity Group consortium funded by the Fogarty International Center to discover new HIV, Malaria and TB drugs from plants in Papua New Guinea.
Dr. Ireland’s research interests include marine pharmacognosy, natural products chemistry, the structure and mechanism of action of antitumor natural products, marine microbiology, and the structure and neurotoxicity of conotoxins. He currently serves on the Editorial Boards of the Journal of Natural Products (1999-present) and the Philippine Journal of Science (1999-present). His professional affiliations include membership in the Organic Chemistry Division of the American Chemical Society, the American Society of Pharmacognosy, and the American Association of Cancer Researchers.
Y. Hwan Kim, Ph.D. earned his B.S. in Plant Physiology/Molecular Biology and M.S. in biotechnology at Korea University, Seoul, South Korea. Under the mentorship of Dr. Art Arnold, Distinguished Professor, Neuroscience/Physiological Science at the University of California, Los Angeles (UCLA), he completed his Ph.D. in Neuroscience while studying sex differences in brain. In addition, he has developed extensive scientific expertise in Parkinson’s disease (PD) research as a post-doctoral fellow at Johns Hopkins Medical Institution and Buck Institute for aging research. Twenty-two years of laboratory experience have prepared him well for broad neuroscience research projects. Currently he is an associate professor at Delaware State University responsible for supervising researchers and graduate students, designing experiments, troubleshooting of research projects, and writing scientific manuscripts. The Kim lab focuses on understanding the role of post-translational modification such as SUMOylation and Ubiquitination of alpha-synuclein in the pathology of Parkinson’s disease and developing potential therapeutic combinations for PD.
A. Douglas Kinghorn, Ph.D., D.Sc, is the inaugural Jack L. Beal Professor and Chair in Natural Products Chemistry and Pharmacognosy, Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio (since 2004). Formerly, he was Professor of Pharmacognosy, Assistant Head of the Department of Medicinal Chemistry and Pharmacognosy, and Associate Director of the Program for Collaborative Research in the Pharmaceutical Sciences at the University of Illinois at Chicago (UIC). He has also served as Gastprofessor at the Swiss Federal Institute of Technology Zurich (ETH Zurich), Switzerland (sabbatical, 1990), and has also been Visiting Professor at the Universities of Salerno (Italy; September, 1996) and São Paulo (Brazil; May, 1997).
Dr. Kinghorn was educated in the United Kingdom, and received degrees from the Universities of Bradford (B. Pharm., 1969), Strathclyde (M.Sc. in Forensic Science, 1970), and London [Ph.D. in Pharmacognosy, 1975; D.Sc. (earned higher doctorate) in Pharmacy, 1990]. He is a Fellow of the Linnean Society of London (1985), the Royal Pharmaceutical Society of Great Britain (1991), and the American Association of Pharmaceutical Scientists (AAPS) (1996). Dr. Kinghorn was designated as the 1993 B. Kenneth West University Scholar (Senior University Scholar) by the University of Illinois Foundation and was awarded the 2002-2003 UIC Award for Excellence in Teaching, the premier peer-reviewed campus teaching award for faculty members. In 2006, he was named as a Fellow of The School of Pharmacy, University of London. Dr. Kinghorn has served as President of both the American Society of Pharmacognosy (1990-1991) and the Society for Economic Botany (1991-1992). Currently, he is Editor-in-Chief of the Journal of Natural Products (1994-2008; co-published by the American Chemical Society and the American Society of Pharmacognosy) and serves also on the Editorial Advisory Boards of fourteen other scientific journals in the fields of natural products, pharmacy, organic chemistry, and cancer. He is Chair of the Dietary Supplements–Botanicals Expert Committee and a Member of the Council of Experts of the United States Pharmacopeia (2005-2010).
Dr. Kinghorn’s research interests are in the isolation, characterization, and biological evaluation of natural products of higher plant origin, and he has worked in particular on compounds with potential oral antimicrobial, cancer chemotherapeutic, cancer chemopreventive, and sweet-tasting effects. He has authored or co-authored about 400 research articles, book chapters, and reviews, and has edited or co-edited four books. Dr. Kinghorn has presented research seminars and lectures at international and national scientific meetings in 30 different countries. In 2001, he was named as a “Highly Cited Researcher” in Agricultural Sciences by the Institute of Scientific Information (ISI), Philadelphia, PA. Dr. Kinghorn has been Major and/or Thesis Advisor for about 40 graduate students and has also directly supervised 60 postdoctorals and visiting scholars.
Stephan Gerhard Thiede, M.D., is a Board-Certified Radiologist [American Board of Radiology (ABR), June, 2003], with additional Certification of Qualification in Neuroradiology from the ABR (November, 2005). He was educated at Oberlin College (Neurosciences/Pre-Med./Economics) and the University of North Carolina School of Medicine, Chapel Hill, NC (M.D., 1998), with additional training at the University of North Carolina Hospitals (Internal Medicine, 1998-1999, and Residency in Diagnostic Radiology, 1999-2003) and the University of Utah Medical Center (Fellowship in Neuroradiology, 2003-2005). Dr. Thiede is a contributor to the authoritative book, Diagnostic Imaging: Head and Neck (1st edition, 2005), and his work has also been published in Pediatric Pulmonology, The American Journal of Respiratory and Critical Care Medicine, and Academic Radiology. He is in private radiology practice with Radiology Associates, P.C., Eugene, OR.
H. Steve White, Ph.D., earned his baccalaureate degree in Pharmacy and a M.S. in Pharmacology at Idaho State University. He earned his Ph.D. in Pharmacology at the University of Utah where he rose through the academic ranks after joining the College of Pharmacy faculty in 1986. Before joining the University Of Washington School Of Pharmacy as Chair of the Department of Pharmacy, White was the principal investigator and scientific director of the NIH-sponsored Anticonvulsant Drug Development (ADD) Program, established in 1975 to identify novel anticonvulsant drugs using established animal seizure and epilepsy models.
White’s research is focused on understanding the factors that contribute to the initiation, propagation, and amelioration of seizure activity. White has been the recipient of significant research funding from the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), and he and his collaborators have published over 170 original papers pertaining to the mechanism of action and the pharmacology of antiepileptic drugs. In addition to his academic service, he served as Research Director of CURE (Citizen’s United for Research in Epilepsy), the largest non-governmental provider of epilepsy research funding, from November 2011 until October of 2015, where he assisted in the development of strategic programs that advance transformative epilepsy research that may someday lead to a cure or disease modifying therapy for the patient at risk for developing epilepsy. He continues to serve as a Research Advisor to CURE’s team-science initiatives. He has been a co-organizer of two NIH-sponsored workshops on models of refractory epilepsy and epileptogenesis and currently serves on the organizing committee of the biannual Eilat Conferences on Antiepileptic Drug Development. Additionally, White has been actively engaged as a mentor for the next generation of neuroscientists and epilepsy educators and is frequently invited to speak at national and international congresses.
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